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GUID is a globally unique identifier. It seems to be used interchangeably with UUID which stands for universally unique identifier. The GUID is a 128-bit quantity that identifies things in the Microsoft universe. A GUID, while treated as an atomic 128-bit unit, has the following partitions:

 32 bits
 16 bits
  8 bits
  8 bits
  8 bytes

In multimedia terms, GUIDs figure prominently in Microsoft's ASF format.